PAF and EZH2 Induce Wnt/β-Catenin Signaling Hyperactivation
نویسندگان
چکیده
منابع مشابه
Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling.
On pathological stress, Wnt signaling is reactivated and induces genes associated with cardiac remodeling and fibrosis. We have previously shown that a cell surface receptor Cdon (cell-adhesion associated, oncogene regulated) suppresses Wnt signaling to promote neuronal differentiation however its role in heart is unknown. Here, we demonstrate a critical role of Cdon in cardiac function and rem...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2013
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2013.08.028